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Pathobiology of colorectal cancer hepatic metastases with an emphasis on prognostic factors
Author(s) -
LeGolvan Mark P.,
Resnick Murray
Publication year - 2010
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21817
Subject(s) - medicine , colorectal cancer , oncology , cancer , emphasis (telecommunications) , colonic disease , general surgery , electrical engineering , engineering
Colorectal cancer is the second leading cause of cancer related death in the United States. The majority of these deaths are due to metastasis, with the liver easily accounting as the most common site of deposit. While there are multiple steps in the CRC hepatic metastatic cascade, this review attempts to summarize the different processes involved, focusing on the most recent discoveries, as well as the associated effects in relation to prognosis. J. Surg. Oncol. 2010;102:898–908. © 2010 Wiley‐Liss, Inc.