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Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients
Author(s) -
Leong Stanley P.L.,
Zuber Markus,
Ferris Robert L.,
Kitagawa Yuko,
Cabanas Ramon,
Levenback Charles,
Faries Mark,
Saha Sukamal
Publication year - 2011
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21815
Subject(s) - medicine , micrometastasis , sentinel lymph node , melanoma , breast cancer , cancer , metastasis , lymph , oncology , nodal , sentinel node , pathology , cancer research
The validation of sentinel lymph node (SLN) concept in melanoma and breast cancer has established a new paradigm in cancer metastasis that, in general, cancer cells spread in a orderly fashion from the primary site to the SLNs in the regional nodal basin and then to the distant sites. In this review article, we examine the development of SLN concept in penile carcinoma, melanoma and breast carcinoma and its application to other solid cancers with emphasis of the relationship between micrometastasis in SLNs and clinical outcomes. J. Surg. Oncol. 2011;103:518–530. © 2011 Wiley‐Liss, Inc.