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Clinicopathologic analysis of adenosquamous/squamous cell carcinoma of the gallbladder
Author(s) -
Kim Woo Seok,
Jang KeeTaek,
Choi Dong Wook,
Choi Seoung Ho,
Heo Jin Seok,
You Dong Do,
Lee Hyung Geun
Publication year - 2010
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21813
Subject(s) - medicine , adenosquamous carcinoma , basal cell , gallbladder , pathology , carcinoma , oncology , adenocarcinoma , cancer
Backgrounds and Objectives Adenosquamous/squamous cell carcinoma (AS/SCC) of the gallbladder is rarely encountered and accounts for 1.4–10.6% of all gallbladder carcinomas (GBCs). This study was conducted to investigate the clinicopathologic features of AS/SCC of gallbladder. Methods The authors retrospectively reviewed 16 cases of pathologically proven AS/SCC of the gallbladder among 404 patients who underwent surgery for GBC from October 1994 to March 2009. Forty‐eight conventional GBC patients were selected as controls after matching for age and gender. Results Mean patient age was 60.2 years and half were male. Tumor stages in the case group were significantly more advanced than the control group ( P < 0.001). R0 resection rates in cases and controls were 50% and 81.2% ( P = 0.022). Overall 1‐year survival in the case group was significantly poorer than in the control group (18.8% vs. 87.3%, P < 0.001). However, no significant difference in disease‐free survival rates was found between cases and controls after R0 resection ( P = 0.072). Conclusions AS/SCC of the gallbladder is often diagnosed at an advanced stage, which results in non‐curative surgical resection and a poorer prognosis than conventional GBC. However, curative surgical resection of AS/SCC of the gallbladder might result in disease‐free survival rates that are comparable with those of conventional GBC. J. Surg. Oncol. 2011; 103:239–242. © 2010 Wiley‐Liss, Inc.