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Prognostic factors after early recurrence in patients who underwent curative resection for hepatocellular carcinoma
Author(s) -
Chun Jae Min,
Kwon Hyung Jun,
Sohn Junho,
Kim Sang Geol,
Park JiYoung,
Bae Han Ik,
Yun Young Kook,
Hwang Yoon Jin
Publication year - 2010
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21786
Subject(s) - medicine , hepatocellular carcinoma , resection , carcinoma , surgery , surgical resection , curative treatment , oncology , general surgery , radiology , disease
Background The prognosis of the patients with early recurrence after curative hepatectomy for hepatocellular carcinoma (HCC) is usually dismal. Methods One hundred twenty‐four patients underwent curative resection for HCC at Kyungpook National University Hospital from January 2002 to December 2006. An early recurrence was defined as a recurrence within 2 years after a curative resection. The risk factors associated with an early recurrence were analyzed as well as other risk factors correlated with survival after early recurrence. Results Early disease recurrence developed in 56 patients (45.2%). The risk factors associated with an early recurrence were a tumor size larger than 5 cm ( P = 0.001) and the presence of tumor micrometastasis ( P < 0.001). The 1 year/2 year overall survival, after early recurrence, was 57.0%/41.0% and the preoperative α‐fetoprotein, C‐reactive protein (CRP), tumor size, macroscopic vascular invasion, and number of tumors were associated with survival on the univariate analysis. The multivariate analysis showed that the independent risk factors for survival, after early disease recurrence, were a preoperative CRP >1.0 mg/dl and macroscopic vascular invasion. ( P = 0.004, P < 0.001, respectively). Conclusion The preoperative CRP and macroscopic vascular invasion were associated with the aggressiveness of early recurrent HCC. J. Surg. Oncol. 2011; 103:148–151. © 2010 Wiley‐Liss, Inc.