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ADAM 10 is associated with gastric cancer progression and prognosis of patients
Author(s) -
Wang YuanYu,
Ye ZaiYuan,
Li Li,
Zhao ZhongSheng,
Shao QinShu,
Tao HouQuan
Publication year - 2010
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21781
Subject(s) - medicine , stage (stratigraphy) , cancer , metastasis , lymph node , lymph , tumor progression , pathology , lymph node metastasis , oncology , cancer research , biology , paleontology
Background The metalloproteinase domain‐containing protein 10 (ADAM 10) has been implicated in the development and progression of gastric cancer. Methods Expression of ADAM 10 and C‐erbB‐2 were examined immunochemically in 436 clinicopathologically characterized gastric cancer cases. Results Protein levels of ADAM 10 and C‐erbB‐2 were up‐regulated in gastric cancer lesions compared with adjacent non‐cancerous tissues. Positive expression of ADAM 10 correlated with age, size of tumor, location of tumor, depth of invasion, vessel invasion, lymph node, and distant metastasis and TNM stage, and also with expression of C‐erbB‐2. In stages I, II, and III, the 5‐year survival rate of patients with high ADAM 10 expression was significantly lower than in patients with low expression. However, in stage IV, ADAM 10 expression did not correlate with the 5‐year survival rate. Further multivariate analysis suggests that up‐regulation of ADAM 10 and C‐erbB‐2 were independent prognostic indicators for the disease, along with depth of invasion, lymph node and distant metastasis and TNM stage. Conclusion Expression of ADAM 10 in gastric cancer is significantly associated with lymph node and distant metastasis, high C‐erbB‐2 expression, and poor prognosis. ADAM 10 and C‐erbB‐2 proteins could be useful markers to predict tumor progression and prognosis. J. Surg. Oncol. 2011; 103:116–123. © 2010 Wiley‐Liss, Inc.