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Lymphangiogenesis and hemangiogenesis: Potential targets for therapy
Author(s) -
Witte Marlys H.,
Dellinger Michael T.,
McDonald Donald M.,
Nathanson S. David,
Boccardo Francesco M.,
Campisi Corradino C.C.,
Sleeman Jonathan P.,
Gershenwald Jeffrey E.
Publication year - 2011
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21714
Subject(s) - lymphangiogenesis , lymphatic system , medicine , cancer , lymphedema , lymphatic endothelium , cancer therapy , pathology , bioinformatics , metastasis , biology , breast cancer
This review updates historical background from century‐old observations on embryonic lymphatic system development through current understanding of the molecular basis of lymphvasculogenesis/lymphangiogenesis (“molecular lymphology”), highlighting similarities and differences with analogous blood vasculature processes. Topics covered include molecular mechanisms in lymphatic development, structural adaptations of the lymphatic vasculature to particulate and cellular transport and trafficking, lymphogenous route of clinical cancer spread, preservation of delineated lymphatic pathways during cancer operations, and anti‐lymphangiogenesis in cancer therapy. J. Surg. Oncol. 2011;103:489–500. © 2011 Wiley‐Liss, Inc.