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Tumor microenvironment and progression
Author(s) -
Dvorak Harold F.,
Weaver Valerie M.,
Tlsty Thea D.,
Bergers Gabriele
Publication year - 2011
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21709
Subject(s) - medicine , tumor microenvironment , epigenetics , cancer research , regulator , bone marrow , tumor progression , vascular endothelial growth factor , homeostasis , pathology , cancer , vegf receptors , tumor cells , biology , biochemistry , gene
Tumor blood vessels are heterogeneous, of at least six distinct types, are induced primarily by vascular endothelial growth factor‐A (VEGF‐A), and provide a potentially useful therapeutic target. Breast cancer is characterized by changes in the microenvironment that result in altered tensional homeostasis. Also, breast cancers arise as the result of epigenetic as well as genetic changes. Tumor blood vessel pericytes result, in part, from bone marrow precursor cells, and VEGF is a negative regulator of glioblastoma tumor cell invasion. J. Surg. Oncol. 2011;103:468–474. © 2011 Wiley‐Liss, Inc.