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Immune response to cancer and its regulation in regional lymph nodes
Author(s) -
Zheng Rongxiu,
Shu Suyu
Publication year - 2011
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21692
Subject(s) - medicine , lymph , immune system , immunotherapy , dendritic cell , cancer research , cancer , cancer immunotherapy , immunology , mechanism (biology) , pathology , philosophy , epistemology
Regional draining lymph nodes (LNs) play a pivotal role in initiating immune responses. However, the presence of metastases may compromise their normal immunological function. Preclinical studies indicate that despite metastases, early tumor‐draining LNs are still a rich source of sensitized T cells. Recently, we found that dendritic (DC)‐tumor fusion hybrids were capable of stimulating therapeutic T‐cell generation in the LN. However, this response is regulated by a tumor‐specific suppression mechanism(s). Reversal of these dysfunctions would help the success of immunotherapy. J. Surg. Oncol. 2011;103:550–554. © 2011 Wiley‐Liss, Inc.