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Molecular mechanisms of metastasis
Author(s) -
Hoon Dave S.B.,
Ferris Robert,
Tanaka Ryo,
Chong Kelly K.,
AlixPanabières Catherine,
Pantel Klaus
Publication year - 2011
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21690
Subject(s) - metastasis , medicine , chemokine , epigenetics , mechanism (biology) , cancer , suppressor , cancer research , primary tumor , cancer metastasis , metastasis suppressor gene , gene , receptor , biology , genetics , philosophy , epistemology
The mechanism of metastasis is a complex set of events that build upon each other to achieve successful growth in organ sites beyond the primary tumor. The cumulative events for metastasis of different cancers have both common and specific cancer specific events. This review discusses several key factors in different cancers that are responsible in metastasis, which includes epigenetic regulation of tumor suppressor genes, functional activity of tumor‐related chemokine receptors, and circulating tumor cells. J. Surg. Oncol. 2011;103:508–517. © 2011 Wiley‐Liss, Inc.