z-logo
Premium
Safety and potential benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in peritoneal carcinomatosis from primary or recurrent ovarian cancer
Author(s) -
Roviello Franco,
Pinto Enrico,
Corso Giovanni,
Pedrazzani Corrado,
Caruso Stefano,
Filippeschi Marco,
Petrioli Roberto,
Marsili Stefania,
Mazzei Maria Antonietta,
Marrelli Daniele
Publication year - 2010
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21682
Subject(s) - medicine , peritoneal carcinomatosis , ovarian cancer , hyperthermic intraperitoneal chemotherapy , cytoreductive surgery , surgery , chemotherapy , cisplatin , cancer , oncology , colorectal cancer
Objectives To analyze the outcomes of cytoreductive surgery and HIPEC in patients with peritoneal carcinomatosis from ovarian cancer. Methods Fifty‐three patients with peritoneal carcinomatosis from primary (45 cases) and recurrent (8 cases) ovarian cancer were previously treated by systemic chemotherapy with platinum and taxanes and then submitted to surgical cytoreduction and HIPEC (cisplatin and mitomycin‐C) with a closed abdomen technique. The median follow‐up period was 27 months (range: 3–107). Results At the end of operation a complete cytoreduction (CCR‐0) was obtained in 37 patients (70%). Major morbidity occurred in 12 patients (23%); reoperation was necessary in 2 patients (4%), and no postoperative mortality was observed. Overall 5‐year survival probability was 55%; it was 71% in CCR‐0, 44% in CCR‐1, and none in patients with CCR‐2 or CCR‐3 residual tumor (log‐rank test: P  = 0.017). The cumulative risk of recurrence in 37 CCR‐0 cases was 54% at 5 years from operation. Conclusions The results of our study indicate the feasibility and the potential benefit of a protocol including systemic chemotherapy, surgical cytoreduction and HIPEC in patients with peritoneal carcinomatosis from ovarian cancer. A phase III trial to compare this approach with conventional treatment is needed. J. Surg. Oncol. 2010;102:663–670. © 2010 Wiley‐Liss, Inc.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here