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Adjuvant radiation therapy is associated with improved survival for adenoid cystic carcinoma of the breast
Author(s) -
Coates Jodi M.,
Martinez Steve R.,
Bold Richard J.,
Chen Steven L.
Publication year - 2010
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21638
Subject(s) - medicine , adenoid cystic carcinoma , adjuvant , oncology , adjuvant radiotherapy , radiation therapy , breast carcinoma , adjuvant therapy , carcinoma , breast cancer , chemotherapy , cancer
Background The role of adjuvant radiation therapy (RT) for adenoid cystic carcinoma (ACC) of the breast remains unclear. Materials and Methods We queried the Surveillance, Epidemiology, and End Results database for patients with breast ACC resected between 1988 and 2005, and divided patients based on the receipt of RT. Univariate and multivariate survival comparisons were made for overall and disease‐specific survival. Results Three hundred seventy six patients met criteria for inclusion. Demographics and staging were similar between groups. Univariate analysis revealed an absolute overall and cause‐specific survival benefit of 21% and 7% at 10 years ( P = 0.005 and P = 0.12 respectively). In the multivariate analysis, RT was a significant predictor of overall and cause‐specific survival with hazard ratios of 0.44 (95% Confidence interval (CI) = 0.22–0.88) and 0.1 (95% CI: 0.01–0.88), respectively. Conclusions RT after local surgical therapy for ACC of the breast improved both cause‐specific and overall survival. Use of RT in this rare tumor should be considered in patients otherwise eligible for RT. J. Surg. Oncol. 2010;102:342–347. © 2010 Wiley‐Liss, Inc.