Premium
Adenoma incidence after resection of sporadic colorectal cancer with microsatellite instability
Author(s) -
Kang Ki Joo,
Sinn Dong Hyun,
Park Sung Hyun,
Kim Jin Yong,
Chang Dong Kyung,
Son Hee Jung,
Rhee PoongLyul,
Kim Jae J.,
Rhee Jong Chul,
Chun HoKyung,
Kim YoungHo
Publication year - 2010
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21548
Subject(s) - microsatellite instability , medicine , incidence (geometry) , adenoma , colorectal cancer , colonoscopy , gastroenterology , oncology , colorectal adenoma , cancer , microsatellite , gene , biology , genetics , allele , physics , optics
Background and Objectives Microsatellite instability (MSI) tumors that develop via the mismatch repair (MMR) gene pathway show rapid growth. It is unknown if patients with sporadic colorectal cancer (CRC) with MSI would benefit from a shorter interval between colonoscopies. The purpose of this study is to determine if there is a difference in adenoma incidence based on the presence of MSI in patients with sporadic CRC. Methods We retrospectively reviewed the incidence of a recurring adenoma at the 1‐ and 3‐year surveillance colonoscopies in 426 patients who had sporadic CRC after surgery Results The number of high MSI (MSI‐H), low MSI (MSI‐L), and microsatellite stable (MSS) tumors were 38 (9%), 27 (6%), and 361 (85%), respectively. After 1 year, the incidence of adenoma (13% vs. 16% for MSI‐L + MSS vs. MSI‐H, P = 0.61) or advanced adenoma (3% vs. 8% for MSI‐L + MSS vs. MSI‐H, P = 0.14) did not differ based on MSI status. The incidence of adenoma or advanced adenoma also did not differ based on MSI status at the 3‐year surveillance colonoscopy. Conclusions Our study does not show recommendations for a shorter interval for subsequent colonoscopies in patients with sporadic CRC with MSI‐H. Further studies on a large scale are needed. J. Surg. Oncol. 2010; 101:577–581. © 2010 Wiley‐Liss, Inc.