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Pelvis and extremity osteosarcoma with similar tumor volume have an equivalent survival
Author(s) -
Song Won Seok,
Cho Wan Hyeong,
Jeon DaeGeun,
Kong ChangBae,
Kim Min Suk,
Lee Jun Ah,
Shawky Eid Ahmed,
Kim JaeDo,
Lee SooYong
Publication year - 2010
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21540
Subject(s) - medicine , osteosarcoma , pelvis , surgery , chemotherapy , radiology , pathology
Background and Objectives The poor prognosis of pelvic osteosarcoma is well recognized, but the cause of this prognosis has not been well defined. Methods We analyzed the clinicopathologic characteristics of pelvic osteosarcoma, and their prognostic significances in a cohort of 41 patients, treated either surgically by ablation or non‐surgically. In a separate case‐controlled study, the 20 surgically treated osteosarcoma patients were matched with 38 patients with extremity osteosarcoma by tumor volume and age. Results The 5‐year overall survival rates of the surgically and the non‐surgically treated pelvic osteosarcoma were 55.8 ± 13.0% and 4.8 ± 4.7%, respectively ( P < 0.01). Non‐surgically managed pelvic osteosarcoma group were found to have a larger tumor volume ( P = 0.02), bladder displacement and sacroiliac joint involvement ( P < 0.01). The 5‐year metastasis free survival rates in the surgically treated pelvic and extremity osteosarcoma were no different (41.4 ± 12.8% vs. 48.6 ± 8.4%), and histologic responses to chemotherapy were similar in two groups. Conclusions No significant difference in survival or histologic response was found between the surgically treated pelvic and the extremity osteosarcoma with suitable tumor volume. Outcome of pelvis osteosarcoma corresponds to the poor survival of extremity osteosarcoma of high initial tumor burden. J. Surg. Oncol. 2010; 101:611–617. © 2010 Wiley‐Liss, Inc.