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Clinicopathologic characteristics and prognosis of mucinous gastric carcinoma
Author(s) -
Zhang Ming,
Zhu Guanyu,
Zhang Hongfeng,
Gao Hongyu,
Han Xiaofeng,
Xue Yingwei
Publication year - 2010
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21533
Subject(s) - medicine , stage (stratigraphy) , mucinous carcinoma , lymphovascular invasion , histology , gastric carcinoma , lymph node metastasis , carcinoma , gastroenterology , lymph node , multivariate analysis , oncology , cancer , metastasis , adenocarcinoma , paleontology , biology
Background and Objectives Reports of clinicopathological features and prognosis in patients with mucinous gastric carcinoma (MGC) are conflicting. The aim was to describe the clinicopathological features and prognosis of patients with MGC in comparison with nonmucinous gastric carcinoma (NMGC). Methods We reviewed the records of 1,278 consecutive patients diagnosed with gastric carcinoma who were resected surgically from 1993 to 2003. Among them, 48 patients (3.8%) with MGC were compared to 1,230 patients with NMGC. Results There were significant differences in tumor location, stage of disease, lymphatic invasion, and vascular invasion between the patients with MGC and NMGC. The overall 5‐year survival of patients with MGC was 27.2% as compared with 42.8% for patients with NMGC ( P = 0.031). For the patients with the same stage, there was no significant difference between MGC and NMGC. With respect to patients with MGC, multivariate analysis showed that lymph node metastasis and curative resection were significant factors affecting survival. Conclusions MGC is rare and detected mostly in an advanced stage. Mucinous histology type itself is not an independent prognostic factor. J. Surg. Oncol. J. Surg. Oncol. 2010;102:64–67. © 2010 Wiley‐Liss, Inc.