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Predictive factors of carcinoma in 279 patients with Hürthle cell neoplasm of the thyroid gland
Author(s) -
Strazisar Branka,
Petric Rok,
Sesek Manja,
Zgajnar Janez,
Hocevar Marko,
Besic Nikola
Publication year - 2010
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21526
Subject(s) - medicine , malignancy , logistic regression , carcinoma , thyroid , thyroid carcinoma , neoplasm , adenoma , cancer , retrospective cohort study , thyroid cancer , goiter , gastroenterology , pathology
Abstract Background and Objectives Estimation of the risk of malignancy in a Hürthle cell (HC) neoplasm is important for optimum extent of thyroid surgical treatment. The aim of this retrospective study was to find predictive factors of carcinoma in patients with HC neoplasm. Methods A total of 279 patients (241 females, 38 males; median age 55 years, range 15–86 years) with HC neoplasm in whom carcinoma was only suspected and who were surgically treated at our Institute in the period 1990–2007, were included in this study. Risk factors for malignancy were identified by the chi‐squared test and logistic regression. Results The histopatological diagnoses were carcinoma, benign goiter and adenoma in 71 (25%), 68 (25%) and 140 (50%) patients, respectively. Predictive factors for carcinoma, shown by chi‐square test, were: age of patients, tumor diameter, thyroid volume and T g concentration. The independent predictors of malignancy as shown by multivariate logistic regression were age of patients and pre‐operative T g concentration. Carcinoma was more common in the patients older than 65 years of age and with T g concentration over 1,000 ng/ml. Conclusions The independent predictors of malignancy in HC neoplasm were age of patients and pre‐operative T g concentration. J. Surg. Oncol. 2010; 101:582–586. © 2010 Wiley‐Liss, Inc.