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Ulcerative colitis and cancer
Author(s) -
Kulaylat Mahmoud N.,
Dayton Merril T.
Publication year - 2010
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21505
Subject(s) - medicine , ulcerative colitis , colorectal cancer , cancer , colitis , gastroenterology , pathology , oncology , disease
Patients with ulcerative colitis (UC) are at an increased risk for the development of colorectal cancer (CRC). Unlike sporadic CRC, the cancer in UC patients arises from a focal or multifocal dysplastic mucosa in areas of inflammation. The clinical features of UC‐associated cancer are similar to those found in patients with hereditary non‐polyposis colorectal cancer. As with other varieties of CRC, UC‐associated cancer exhibits a variety of genetic and molecular changes/abnormalities. These abnormalities are however clustered in areas of mucosae with histological abnormalities. The magnitude and timing of these changes are however significantly different. Surveillance and identification of patients at risk for cancer are a challenging problem. J. Surg. Oncol. 2010; 101:706‐712. © 2010 Wiley‐Liss, Inc.