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Loss of E‐cadherin and β‐catenin is correlated with poor prognosis of ampullary neoplasms
Author(s) -
Hsu HuiPing,
Shan YanShen,
Jin YingTai,
Lai MingDerg,
Lin PinWen
Publication year - 2010
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21493
Subject(s) - medicine , cadherin , catenin , oncology , cell , genetics , wnt signaling pathway , biology , gene
Background and Objectives Distant metastasis resulting from carcinoma cell detachment from the primary tumor involves modification of adhesion molecules. This study was conducted to examine the correlation of E‐cadherin/β‐catenin expression with survival and recurrence in ampullary neoplasms. Methods Patients with diagnoses of ampullary neoplasms were enrolled in the study. Demographics, operative findings, and histopathological data were collected by retrospective chart review. Expression of E‐cadherin and β‐catenin were detected by immunohistochemistry. Results A total of 110 patients were enrolled in the study. Preservation of membranous staining of E‐cadherin was noted in 41 (37%) patients, aberrant cytoplasmic staining in 48 (44%) patients, and complete loss in 21 (19%) patients. Loss of E‐cadherin was associated with pancreatic invasion, recurrence, and poor prognosis. Membranous staining of β‐catenin was noted in 65 (59%) patients, cytoplasmic or nuclear accumulation in 16 (15%) patients, and complete loss in 29 (26%) patients. Loss of β‐catenin expression was associated with tumor markers, ulcerative type, liver metastases, and poor prognosis. Pancreatic invasion, lymph node involvement, and loss of β‐catenin expression were predictors of disease recurrence. Conclusions Loss of the E‐cadherin/β‐catenin complex is related to poor prognosis in ampullary cancer. Loss of β‐catenin is predictor of recurrence in multivariate analysis. J. Surg. Oncol. 2010; 101:356–362. © 2010 Wiley‐Liss, Inc.