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Neoadjuvant therapy of locally advanced gastric cancer
Author(s) -
Mezhir James J.,
Tang Laura H.,
Coit Daniel G.
Publication year - 2010
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21483
Subject(s) - medicine , neoadjuvant therapy , oncology , chemotherapy , cancer , complete response , disease , randomized controlled trial , clinical trial , overall survival , surgery , breast cancer
Treatment of gastric cancer has evolved with the advent of randomized trials demonstrating chemotherapeutic agents with efficacy in advanced disease. Level I evidence supports delivering chemotherapy in the neoadjuvant setting; the data shows improvement in progression‐free and overall survival. A clinical response to therapy is associated with improved R0 resection rates, pathologic response, and outcome in patients with locally advanced disease. Early assessment of metabolic response to therapy can potentially be utilized to tailor treatment. J. Surg. Oncol. 2010; 101:305–314. © 2010 Wiley‐Liss, Inc.