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Current neoadjuvant strategies in rectal cancer
Author(s) -
Julien Lucas A.,
Thorson Alan G.
Publication year - 2010
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21480
Subject(s) - medicine , colorectal cancer , schema (genetic algorithms) , neoadjuvant therapy , disease , radiation therapy , chemotherapy , modalities , oncology , treatment modality , intensive care medicine , general surgery , cancer , surgery , social science , machine learning , sociology , breast cancer , computer science
Abstract Treatment modalities in rectal cancer have undergone a slow, evolutionary transition over the past 30 years. More recently, contemporary descriptions of advanced preoperative chemotherapy and radiation schema have led to a rapid revolution in the management of this disease. In this review we focus on current evidence‐based neoadjuvant strategies used in the treatment of locally advanced rectal cancer and metastatic rectal disease. Finally, we provide a foundation for discussion of still unresolved issues. J. Surg. Oncol. 2010; 101:321–326. © 2010 Wiley‐Liss, Inc.