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Neoadjuvant strategies for the treatment of locally advanced esophageal cancer
Author(s) -
Hyngstrom John R.,
Posner Mitchell C.
Publication year - 2010
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21479
Subject(s) - medicine , esophageal cancer , neoadjuvant therapy , oncology , chemotherapy , chemoradiotherapy , randomized controlled trial , surgery , intensive care medicine , cancer , breast cancer
Patients with locally advanced esophageal carcinoma have consistently poor survival following surgery with associated high systemic and local‐regional failure rates. Neoadjuvant therapeutic strategies have been employed in an attempt to improve outcome with variable success. Randomized trials of either neoadjuvant chemotherapy or chemoradiotherapy have shown conflicting results regarding survival and local‐regional control. Future efforts should focus on identifying novel agents and targets to improve therapeutic efficacy. J. Surg. Oncol. 2010; 101:299–304. © 2010 Wiley‐Liss, Inc.