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Metalloproteinases and their regulators in colorectal cancer
Author(s) -
van der Jagt Michel F.P.,
Wobbes Theo,
Strobbe Luc J.A.,
Sweep Fred C.G.J.,
Span Paul N.
Publication year - 2009
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21462
Subject(s) - medicine , colorectal cancer , matrix metalloproteinase , cancer , oncology
Metalloproteinases (MPs) such as the matrix metalloproteinases (MMPs) and adamalysins (ADAMs and ADAMTS) are expressed in various stages of colorectal cancer (CRC), and some correlate with survival and prognosis. The MPs are regulated by various factors including EMMPRIN, TIMPs, and RECK. In addition, micro‐RNAs are found to be relevant for both MP expression levels and CRC prognostication. Both MPs and their regulators could be potential targets for intervention and therapy in CRC. J. Surg. Oncol. 2010; 101:259–269. © 2009 Wiley‐Liss, Inc.