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Does intrahepatic cholangiocarcinoma have better prognosis compared to perihilar cholangiocarcinoma?
Author(s) -
Guglielmi Alfredo,
Ruzzenente Andrea,
Campagnaro Tommaso,
Pachera Silvia,
Valdegamberi Alessandro,
Capelli Paola,
Pedica Federica,
Nicoli Paola,
Conci Simone,
Iacono Calogero
Publication year - 2010
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21452
Subject(s) - medicine , intrahepatic cholangiocarcinoma , perineural invasion , pathological , univariate analysis , vascular invasion , lymph node , survival rate , klatskin tumor , overall survival , bile duct , gastroenterology , radiology , surgery , resection , cancer , multivariate analysis
Background and Objectives Cholangiocarcinoma can be classified as intrahepatic (ICC) or perihilar (PCC). The objectives of this study is to evaluate the surgical outcomes of patients with PCC and ICC, identify the main prognostic factors related to survival and compare the outcome and the prognostic factors of PCC and ICC. Methods Ninety‐five out of 152 patients observed between January 1990 and December 2007 at Surgical Division of University of Verona Medical School underwent the resection of ICC (33 patients) or PCC (62 patients). Results Overall median survival was 24 months with a 3‐ and 5‐year survival rate of 45% and 23%, respectively. Prognostic factors for survival were macroscopic types of the tumor, the resection of extrahepatic bile duct, radical resection, lymph node metastases, and macro‐vascular invasion. Survival was related with the macroscopic type of the tumors with a 5‐year survival rate of 26% and 13% for ICC and PCC, respectively. Univariate analysis identified that negative clinico‐pathological factors where significant more frequently found in PCC compared to ICC. Conclusion We identified that ICC have longer survival rate compared to PCC. PCC showed a higher frequency of negative clinico‐pathological factors such as non‐radical (R+) resection, perineural infiltration and macro‐vascular invasion. J. Surg. Oncol. 2010;101:111–115. © 2009 Wiley‐Liss, Inc.