Premium
Genomic expression, chemotherapy response, and molecular targets in soft tissue sarcomas of the extremities: Promising strategies for treatment selection
Author(s) -
Aguiar Samuel,
da Cunha Isabela Werneck,
Lopes Ademar
Publication year - 2009
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21422
Subject(s) - medicine , chemotherapy , soft tissue , adjuvant chemotherapy , oncology , sarcoma , selection (genetic algorithm) , bioinformatics , pathology , cancer , biology , artificial intelligence , breast cancer , computer science
Neoadjuvant or adjuvant therapy in soft tissue sarcomas is still controversial, especially in regards to the use of chemotherapy. The identification of predictive factors is crucial to avoid the use of chemotherapy in patients with tumors that carry genetic characteristics associated with resistance. Focusing on gene expression data, we performed a review of the actual state of knowledge in molecular predictive factors for chemotherapy response and new targets of therapy in extremity sarcomas. J. Surg. Oncol. 2010;101:92–96. © 2009 Wiley‐Liss, Inc.