Premium
The impact of anatomical resection for hepatocellular carcinoma that meets the milan criteria
Author(s) -
Kamiyama Toshiya,
Nakanishi Kazuaki,
Yokoo Hideki,
Kamachi Hirofumi,
Matsushita Michiaki,
Todo Satoru
Publication year - 2009
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21414
Subject(s) - medicine , hepatocellular carcinoma , resection , milan criteria , multivariate analysis , univariate analysis , carcinoma , surgical resection , surgery , liver transplantation , transplantation
Background The aim of this study was to analyze the impact of anatomical resection for hepatocellular carcinoma (HCC) that meets the Milan criteria. Methods Between 1990 and 2006, 322 consecutive patients with HCC who met the Milan criteria underwent curative resection (R0) and were classified into two groups: Group A (patients with a single HCC, with a tumor diameter of 5 cm or less) and Group B (patients with multiple tumors, no more than three tumor nodules, each with a diameter of 3 cm or less). Patient survival (PS), recurrence‐free survival rates (RFS), and risk factors were analyzed. Results Univariate analysis revealed that in Group A, anatomical resection was the significant factor related to PS, while anatomical resection was that related to RFS. Multivariate analysis showed that in Group A, anatomical resection was a significant favorite factor associated with PS and RFS. Univariate analysis for Group B revealed that anatomical resection was the significant factor related to PS, while that related to RFS was the anatomical resection. Multivariate analysis showed that anatomical resection was a significant favorite factor for only RFS in Group B. Conclusion Anatomical resection improved the surgical outcome of the patients with HCC which met the Milan criteria. J. Surg. Oncol. 2010;101:54–60. © 2009 Wiley‐Liss, Inc.