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Fascin expression in progression and prognosis of hepatocellular carcinoma
Author(s) -
Iguchi Tomohiro,
Aishima Shinichi,
Umeda Kenji,
Sanefuji Kensaku,
Fujita Nobuhiro,
Sugimachi Keishi,
Gion Tomonobu,
Taketomi Akinobu,
Maehara Yoshihiko,
Tsuneyoshi Masazumi
Publication year - 2009
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21377
Subject(s) - fascin , medicine , hccs , filopodia , immunohistochemistry , hepatocellular carcinoma , metastasis , invadopodia , motility , oncology , pathology , cancer research , cell , cancer , biology , microbiology and biotechnology , genetics
Background and Objectives Fascin is an actin‐bundling protein and induces membrane protrusions and cell motility after the formation of lamellipodia or filopodia. Fascin expression has been reported to be associated with progression or prognosis in various neoplasms, but the role of fascin in hepatocellular carcinoma (HCC) remains unknown. The aim of this study was to investigate the clinicopathological and prognostic relevance of fascin by immunohistochemistry. Methods A total of 137 patients with HCC were stained with anti‐fascin antibody. The tumor cells having unequivocal cytoplasmic and/or membranous fascin immunoreactivity were defined as fascin‐positive. Results Immunohistochemically, 23 (16.8%) HCCs having unequivocal fascin immunoreactivity were found. Tumors showing fascin expression were larger and less differentiated than those showing no fascin expression ( P = 0.0239 and 0.0018, respectively). Portal venous invasion, bile duct invasion, and intrahepatic metastasis were detected significantly more frequently in fascin‐positive group ( P = 0.0029, 0.0333, and 0.0403, respectively). In addition, high alpha‐fetoprotein (AFP) levels were significantly associated with the fascin expression in HCC ( P = 0.0116). Fascin‐positive group had significantly poorer outcomes than fascin‐negative group and was an independent prognostic factor for disease‐free survival. Conclusions Fascin might become a novel marker of progression in HCC and a significant indicator of a poor prognosis for patients with HCC. J. Surg. Oncol. 2009;100:575–579. © 2009 Wiley‐Liss, Inc.