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Increments of α‐dystroglycan expression in liver metastasis correlate with poor survival in gastric cancer
Author(s) -
Moon Yong Wha,
Rha Sun Young,
Zhang Xianglan,
Jeung HeiCheul,
Yang Woo Ick,
Kwon Obin,
Jeong Jae Heon,
Cheon Sung Hah,
Yoo Nae Choon,
Chung Hyun Cheol
Publication year - 2009
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21347
Subject(s) - medicine , cancer , metastasis , oncology , dystroglycan , expression (computer science) , gastroenterology , cancer research , laminin , extracellular matrix , genetics , biology , computer science , programming language
Background Dystroglycan (DG) is a recently focused adhesion molecule with possible roles in cancer development and progression. We investigated correlations between α‐DG expression and prognosis in gastric carcinoma with liver metastasis. Methods For 40 patients with gastric adenocarcinoma and liver‐only metastasis, α‐DG expression was determined by immunohistochemistry in paraffin‐embedded surgical specimens of resected stomach tumor, resected liver metastasis, and their normal counterpart tissues. Correlations between α‐DG expression and prognosis were retrospectively analyzed. Results α‐DG expression was higher in primary gastric cancer ( P = 0.006) and lower in liver metastasis ( P = 0.002) than in each normal counterpart. In primary stomach cancer, patients who had lower α‐DG expression in tumors than in normal counterparts showed poor overall survival (OS) ( P = 0.028). In contrast, in the liver, patients who had higher α‐DG expression in tumors than in normal counterparts showed poor OS ( P = 0.022). Also, higher α‐DG expression in liver metastasis than in stomach tumors led to poor recurrence‐free survival ( P = 0.023) and OS ( P = 0.056). Conclusions This approach may be used to further understanding of the pathogenesis of liver metastasis from gastric cancer. Further studies are warranted to reveal the mechanisms of α‐DG dysregulation in liver metastasis. J. Surg. Oncol. 2009;100:459–465. © 2009 Wiley‐Liss, Inc.