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Local and systemic control of Ewing's bone sarcoma family tumors of the ribs
Author(s) -
Briccoli Antonio,
Rocca Michele,
Salone Mariacristina,
Palmerini Emanuela,
Balladelli Alba,
Ferrari Cristina,
Di Fiore Maria,
Bacci Gaetano
Publication year - 2009
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21337
Subject(s) - medicine , rib cage , chemotherapy , radiation therapy , sarcoma , retrospective cohort study , surgery , systemic therapy , complete response , oncology , cancer , pathology , breast cancer , anatomy
Background A retrospective analysis of the results and relapse pattern was evaluated in 34 patients with Ewing's family bone tumors (EFBT) treated at Rizzoli Institute with neoadjuvant chemotherapy between 1983 and 2003. Objectives The aim of the study was to evaluate treatment strategy and compare our results with those obtained in other studies. Methods Local treatment in these patients was radiotherapy alone in 4 cases, surgery alone in 13 and surgery followed by radiotherapy in 17. Results Five‐year event‐free survival (EFS) was 44%, no different from that observed in another 558 patients with EFBT located in other sites treated in the same period with neoadjuvant chemotherapy protocols. Eighteen patients had a systemic relapse, followed by local relapse in two and one patient had a local relapse alone. EFS was significantly correlated to the time interval between onset symptoms and beginning of treatment and, in operated patients to histologic response to preoperative treatment. Conclusions We conclude that EFBT of the ribs, when treated with neoadjuvant chemotherapy, have an outcome similar to that of patients with EFBT located in other sites. J. Surg. Oncol. 2009;100:222–226. © 2009 Wiley‐Liss, Inc.