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Young age is not associated with increased local recurrence for DCIS treated by breast‐conserving surgery and radiation
Author(s) -
Turaka Aruna,
Freedman Gary M.,
Li Tianyu,
Anderson Penny R.,
Swaby Ramona,
Nicolaou Nicos,
Goldstein Lori,
Sigurdson Elin R.,
Bleicher Richard J.
Publication year - 2009
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21284
Subject(s) - medicine , ductal carcinoma , breast conserving surgery , confidence interval , tamoxifen , radiation therapy , demographics , adjuvant radiotherapy , surgery , mastectomy , breast cancer , cancer , demography , sociology
Background We report local recurrence (LR) after breast‐conserving surgery and radiation (BCS + RT) for ductal carcinoma in situ (DCIS) to determine outcomes for patients aged ≤40 years compared with older women. Methods The study included 440 women with DCIS treated from 1978 to 2007. All patients received whole‐breast radiotherapy with a boost in 95% of cases. Demographics, characteristics, surgical, and adjuvant treatments were analyzed for an effect on LR. Results Median age was 56.5 years with 24 patients aged ≤40. Median DCIS size was 0.8 cm. Re‐excision was required in 62% of patients, and in 75% of those aged ≤40. Tamoxifen was used in 22%, but only one patient aged ≤40. Median follow‐up was 6.8 years. Actuarial LR was 7% (95% confidence interval of 4–11%) at 10 years and 8% (5–14%) at 15 years. There was no difference in LR by age ( P = 0.76). Conclusions The long‐term risk of LR after BCS + RT for DCIS is low, even in patients ≤40 years. This may be due to patient selection for small size, high utilization of re‐excision, and radiation boost. Young age may be a smaller contributor to LR risk in DCIS than previously suggested. J. Surg. Oncol. 2009;100:25–31. © 2009 Wiley‐Liss, Inc.