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Genomic profiling of breast cancer
Author(s) -
Pandey Anjita,
Singh Alok Kumar,
Maurya Sanjeev Kumar,
Rai Rajani,
Tewari Mallika,
Kumar Mohan,
Shukla Hari S.
Publication year - 2009
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21249
Subject(s) - breast cancer , malignancy , gene , medicine , dna repair , genome , bioinformatics , computational biology , genetics , cancer , biology
Genome study provides significant changes in the advancement of molecular diagnosis and treatment in Breast cancer. Several recent critical advances and high‐throughput techniques identified the genomic trouble and dramatically accelerated the pace of research in preventing and curing this malignancy. Tumor‐suppressor genes, Proto‐oncogenes, DNA‐repair genes, Carcinogen‐metabolism genes are critically involved in progression of breast cancer. We reviewed imperative finding in breast genetics, ongoing work to segregate further susceptible genes, and preliminary studies on molecular profiling. J. Surg. Oncol. 2009;99:386–392. © 2009 Wiley‐Liss, Inc.