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Prognostic value of the ratio of metastatic lymph nodes in gastric cancer: An analysis based on a Chinese population
Author(s) -
Wang Xi,
Wan Fei,
Pan Jun,
Yu GuanZhen,
Chen Ying,
Wang JieJun
Publication year - 2009
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21247
Subject(s) - medicine , multivariate analysis , oncology , cancer , lymph , multivariate statistics , population , gastroenterology , pathology , statistics , mathematics , environmental health
Background and Objectives To determine the prognostic value of the ratio of metastatic lymph nodes (RML) for gastric cancer and compare it to the prognostic value of the number‐based pN classification. Methods The survival of 513 patients who underwent curative resection between 2000 and 2005 was retrieved. The prognostic value of two factors for nodal status: RML classification (RML0, 0%; RML1, ≤30%; RML2, ≤50%; RML3, >50%) and pN classification (6th TNM system), was analyzed. Results Both RML and pN classifications were independent prognostic factors when considered separately in multivariate analysis ( P ‐values < 0.05). Moreover, the proportion of explained variation (PEV) analysis showed that each classification had more prognostic value than other prognostic factors in two models respectively ( P ‐values < 0.05). The D‐measure for prognostic separation was 1.563 versus 1.383 for RML versus pN. Bootstrap results for the difference of D‐measures did not show a significant difference between RML and pN in terms of prognostic power (95% CI, −0.102 to 0.175). Conclusions RML is an independent prognostic factor for gastric cancer. However, no significant evidence is found to support the hypothesis that RML classification carries more prognostic value than pN classification. J. Surg. Oncol. 2009;99:329–334. © 2009 Wiley‐Liss, Inc.