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Does chemotherapy increase morbidity and mortality after pneumonectomy?
Author(s) -
Alan Stolz,
Jan Simonek,
Tomas Harustiak,
Robert Lischke,
Jan Schutzner,
Pavel Pafko
Publication year - 2008
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21181
Subject(s) - medicine , bronchopleural fistula , pneumonectomy , empyema , surgery , incidence (geometry) , chemotherapy , retrospective cohort study , lung cancer , physics , optics
Background The impact of chemotherapy on postoperative complications after pneumonectomy remains unclear, and the procedure is often considered as potentially dangerous. Methods This retrospective review of prospectively collected data included 269 patients operated from January 1, 1998 through December 31, 2007. Group 1 included patients those who received preoperative chemotherapy (PCT) and pneumonectomy (54 patients, 20%), and group 2 included patients who underwent pneumonectomy alone (215 patients, 80%). Results Overall 30‐ and 90‐day mortality rates were 5.9% and 8.9%, respectively. Postoperative mortality at 30 days was 5.6% in group 1 and 6% in group 2 ( P = 0.16), and 11.1% for group 1 and 8.3% in group 2 at 90 days ( P = 0.8). Incidence of postoperative respiratory failure was 3.7% in group 1 and 3.2% in group 2 ( P = 0.62); incidence of empyema was 5.5% in group 1 and 2.8% in group 2 ( P = 0.1). Incidence of bronchopleural fistula (BPF) was 3.7% in group 1 and 2.8% in group 2 ( P = 0.55); risk of BPF was higher following right pneumonectomy (6.1%) versus left pneumonectomy (0%, P = 0.003). Conclusions PCT does not significantly increase postoperative morbidity and early mortality after pneumonectomy in our experience. J. Surg. Oncol. 2009;99:38–41. © 2008 Wiley‐Liss, Inc.