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Outcomes of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal mesothelioma: The Australian experience
Author(s) -
Chua Terence C.,
Yan Tristan D.,
Morris David L.
Publication year - 2008
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21177
Subject(s) - medicine , cytoreductive surgery , hyperthermic intraperitoneal chemotherapy , peritoneal mesothelioma , mesothelioma , chemotherapy , intraperitoneal chemotherapy , surgery , oncology , general surgery , cancer , pathology , ovarian cancer
Aims Peritoneal mesothelioma is a rapidly progressing malignancy with a median survival of 6–12 months. Palliative surgery, chemotherapy and radiotherapy are futile and have not shown to improve survival. This paper reports the outcomes of cytoreductive surgery (CRS) and Hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of this disease. Patients and Methods An observational study of 20 patients with peritoneal mesothelioma treated with CRS and HIPEC at the St George Hospital, Sydney, Australia. Survival analysis was performed using the Kaplan–Meier method and comparison using the Log Rank test. Results There were six females. The mean age was 55.7 (9.0) years. The median survival was 29.5 (0.46–87.2) months with 1‐ and 3‐year survival of 78.2% and 46.3%, respectively. Survival was found to be influenced by completeness of cytoreduction ( P = 0.02) and histological subtype ( P = 0.01). Patients with epitheloid peritoneal mesothelioma who had a CC0 had a median survival of 87.2 months. Conclusion CRS and HIPEC is a treatment option for peritoneal mesothelioma. Patients with epithelioid tumor who undergo complete cytoreduction may potentially benefit from this procedure. J. Surg. Oncol. 2009;99: 109–113. © 2008 Wiley‐Liss, Inc.