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Elevated preoperative serum carcinoembrionic antigen level may be an effective indicator for needing adjuvant chemotherapy after potentially curative resection of stage II colon cancer
Author(s) -
Ogata Yutaka,
Murakami Hidetsugu,
Sasatomi Teruo,
Ishibashi Nobuya,
Mori Shinjiro,
Ushijima Masataka,
Akagi Yoshito,
Shirouzu Kazuo
Publication year - 2008
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21161
Subject(s) - medicine , colorectal cancer , chemotherapy , adjuvant , stage (stratigraphy) , adjuvant therapy , surgery , cancer , univariate analysis , adjuvant chemotherapy , carcinoembryonic antigen , survival rate , oncology , gastroenterology , multivariate analysis , breast cancer , paleontology , biology
Background To determine the prognostic factors and to rationalize adjuvant therapy, the clinicopathologic data of patients with a stage II colon cancer were analyzed retrospectively. Patients and Methods A total of 392 patients underwent potentially curative resection at the Kurume University Hospital between 1982 and 2005. Postoperative adjuvant chemotherapy using oral fluoropyrimidines was administered in 163 patients, and the other 229 patients underwent surgery alone. Univariate and multivariate analyses for prognostic factors were carried out. Results Invasive type in gross features, elevated preoperative CEA level, and surgery alone were each an independently significant factor for shorter relapse‐free survival, and tumor size <50 mm, invasive type in gross features, elevated preoperative CEA level, and surgery alone were each an independently significant factor for shorter overall survival. The relapse‐free survival rate and overall survival rate in the patients who received postoperative adjuvant chemotherapy were significantly higher than those in the patients treated with surgery alone even after stratifying to the preoperative CEA level. Conclusion Patients with an elevated preoperative CEA may be candidates for adjuvant chemotherapy after curative resection in stage II colon cancer. These findings warrant clinical trials to test out the efficacy of adjuvant chemotherapy in stage II colon cancer with an elevated preoperative CEA. J. Surg. Oncol. 2009;99:65–70. © 2008 Wiley‐Liss, Inc.