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Molecular determinants of outcomes: Linking tissue banks to outcomes databases
Author(s) -
Bathe Oliver F.
Publication year - 2009
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21152
Subject(s) - medicine , biomarker , linkage (software) , molecular biomarkers , genetic data , affect (linguistics) , outcomes research , research data , database , oncology , bioinformatics , data science , pathology , environmental health , alternative medicine , gene , genetics , psychology , data curation , population , communication , biology , computer science
Abstract In the past, most outcomes research has focused on defining the clinicopathological determinants of outcomes. More recently, it has become apparent that the molecular features of tumor (as well as the genetic makeup of the patient) significantly influence outcomes, including responsiveness to therapy and prognosis. In view of this, there is a need for more research on the molecular determinants of outcomes. Research biorepositories are important vehicles for this type of research and they could potentially accelerate this work. For biomarker research to affect patient care, it is critical to effectively link patient outcomes data with descriptions of the molecular features of tumors. Effective linkage of outcomes data with tissue banks will dramatically accelerate biomarker research. J. Surg. Oncol. 2009;99:513–516. © 2009 Wiley‐Liss, Inc.