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A rationale for the targeted treatment of oligometastases with radiotherapy
Author(s) -
MacDermed Dhara M.,
Weichselbaum Ralph R.,
Salama Joseph K.
Publication year - 2008
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21102
Subject(s) - medicine , radiation therapy , radiosurgery , targeted therapy , oncology , radiology , cancer
An oligometastatic state has been proposed wherein patients with metastases limited in number and location may benefit from local therapy directed at all known sites of metastases. We describe here the clinical and biological basis for the oligometastatic state. We present evidence for a potentially curative approach to patients with oligometastases using stereotactic body radiotherapy (SBRT) and we review the literature for SBRT directed at specific metastatic sites in the lungs, liver and multiple organs. J. Surg. Oncol. 2008;98:202–206. © 2008 Wiley‐Liss, Inc.