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The significance of ANXA7 expression and its correlation with poor cellular differentiation and enhanced metastatic potential of gastric cancer
Author(s) -
Hsu PingI,
Huang MingShyan,
Chen HuiChun,
Hsu PingNing,
Lai TsungChing,
Wang JuiLing,
Lo GinHo,
Lai KwokHung,
Tseng ChingJiunn,
Hsiao Michael
Publication year - 2008
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21046
Subject(s) - medicine , cancer , adenocarcinoma , immunohistochemistry , metastasis , correlation , pathology , cancer research , oncology , geometry , mathematics
Background Annexin‐A7 (ANXA7) exhibits biological and genetic properties expected of a tumor suppressor gene and may play a role in cancer progression. However, the ANXA7 expression in different histological subtypes of gastric adenocarcinomas and its correlation with invasive potentials has not been elucidated. Methods Immunohistochemical staining of ANXA7 for 84 primary gastric adenocarcinomas was performed, and data was correlated with clinicopathological parameters of patients. Results The ANXA7 expression was well correlated with the grade of differentiation of primary tumors. Its expression was detected in 100% (8/8), 64.9% (24/37), 66.7% (2/3), 31.9% (13/31), 0% (0/3), and 0% (0/2) of well‐differentiated tubular, moderately‐differentiated tubular, papillary, poorly differentiated, signet‐ring cell, and mucinous adenocarcinoma, respectively. According to the Lauren's classification, the ANXA7 expression was higher in intestinal type than in diffuse type tumor (71.9% vs. 6.1%, P = 0.003). The loss of expression of ANXA7 expression was significantly related to distant metastasis ( P = 0.04). However, there were no significant associations between the ANXA7 expression and survival of cancer patients ( P = 0.159). Conclusions A striking correlation between ANXA7 expression and cell differentiation of gastric cancer was observed. The loss of expression of ANXA7 is associated with distant metastasis. J. Surg. Oncol. 2008;97:609–614. © 2008 Wiley‐Liss, Inc.