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Prognostic values of pathologic findings and hypoxia markers in 21 patients with salivary duct carcinoma
Author(s) -
Roh JongLyel,
Cho KyungJa,
Kwon Gui Young,
Choi SeungHo,
Nam Soon Yuhl,
Kim Sang Yoon
Publication year - 2008
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21045
Subject(s) - medicine , perineural invasion , lymphovascular invasion , metastasis , oncology , hypoxia (environmental) , radiation therapy , neck dissection , survival rate , multivariate analysis , biomarker , carcinoma , pathology , gastroenterology , cancer , chemistry , organic chemistry , oxygen , biochemistry
Background Salivary duct carcinoma (SDC) is associated with aggressive clinical behavior. Methods We examined the prognostic values of clinicopathologic variables and hypoxia biomarker expression in 21 patients with SDC treated by resection with/without neck dissection and radiotherapy. Tissue microarrays constructed from tumor blocks were stained with monoclonal antibodies to hypoxia‐inducible factor (HIF)‐1α, HIF‐2α, carbonic anhydrase‐9, glucose transporter‐1, and erythropoietin receptor. Locoregional control and survival rates were calculated by the Kaplan–Meier method and prognostic factors were calculated from uni‐ and multivariate analyses. Results The cervical nodal metastasis rate was 67% at initial diagnosis and the distant metastasis rate was 71% during follow‐up. The only significant predictor of distant metastasis was nodal metastasis ( P = 0.006). Actuarial 5‐year locoregional control, distant metastasis‐free survival, and overall survival rates were 57%, 40%, and 44%. Multivariate analysis showed that lymphovascular and perineural invasion and radiotherapy were independent predictors of overall survival ( P < 0.025). None of the hypoxia biomarkers, however, was a significant predictor of locoregional control, distant metastasis, or survival. Conclusions Lymphovascular and perineural invasion, but not hypoxia biomarkers, were significant prognostic factors for patients with SDC. J. Surg. Oncol. 2008;97:596–600. © 2008 Wiley‐Liss, Inc.