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A new limb salvage surgery in cases of high‐grade soft tissue sarcoma using photodynamic surgery, followed by photo‐ and radiodynamic therapy with acridine orange
Author(s) -
Nakamura Tomoki,
Kusuzaki Katsuyuki,
Matsubara Takao,
Matsumine Akihiko,
Murata Hiroaki,
Uchida Atsumasa
Publication year - 2008
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21025
Subject(s) - medicine , photodynamic therapy , surgery , soft tissue sarcoma , acridine orange , soft tissue , sarcoma , pathology , staining , chemistry , organic chemistry
Background To maintain excellent limb function after tumor resection in patients with high‐grade malignant sarcomas, we developed and established a new surgical adjuvant therapy using acridine orange (AO) after intra‐lesional or marginal resection while sparing normal tissues of major nerves, vessels or bones adjacent to the tumor. Method Our AO therapy procedure was combined with photodynamic surgery (PDS), photodynamic therapy (PDT) and radiodynamic therapy (RDT). In this study, 26 patients with primary high‐grade soft tissue sarcomas were treated with AO therapy. Result Results showed a low local recurrence rate (7.7%) and good local recurrence‐free rate (88%) after AO therapy. Limb function of all patients was maintained at 100% of ISOLS criteria. Conclusion Based on these results, we concluded that AO therapy is useful for local control after margin‐positive tumor resection and for preserving excellent limb function in patients with high‐grade soft tissue sarcomas. J. Surg. Oncol. 2008;97:523–528. © 2008 Wiley‐Liss, Inc.