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Current status of FDG‐PET for head and neck cancer
Author(s) -
Wong Richard J.
Publication year - 2008
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21018
Subject(s) - medicine , occult , head and neck cancer , head and neck squamous cell carcinoma , positron emission tomography , pet imaging , head and neck , nuclear medicine , cancer , oncology , radiation therapy , predictive value , standardized uptake value , radiology , pathology , surgery , alternative medicine
18‐FDG‐PET has utility for the identification of the unknown primary head and neck squamous carcinoma, distant metastases or second primary carcinomas, and recurrent HNSCC in the post‐treatment setting. PET has a high negative predictive value in the detection of recurrent HNSCC. Standardized uptake values have demonstrated prognostic value. Limitations of PET include a lower utility for identifying occult nodal metastases and false positive readings from inflammation, infection, muscle activity, and radiation effect. Novel radioactive tracers may enable PET to identify sites of DNA replication, protein metabolism, and hypoxia. J. Surg. Oncol. 2008;97:649–652. © 2008 Wiley‐Liss, Inc.