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Long‐term pancreatic endocrine function following pancreatoduodenectomy with pancreaticogastrostomy
Author(s) -
Murakami Yoshiaki,
Uemura Kenichiro,
Hayashidani Yasuo,
Sudo Takeshi,
Hashimoto Yasushi,
Ohge Hiroki,
Sueda Taijiro
Publication year - 2008
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21004
Subject(s) - medicine , pancreatic fistula , endocrine system , pancreaticoduodenectomy , surgery , pancreatic function , gastroenterology , pancreatic disease , pancreas , hormone
Background and Objectives The aim of this study was to evaluate long‐term pancreatic endocrine function following pancreatoduodenectomy with pancreaticogastrostomy. Methods Records of 52 patients who had survived for three or more years following pancreatoduodenectomy with pancreaticogastrostomy were studied retrospectively. Serum HbA 1c levels had been measured prior to and at 3‐ to 6‐month intervals after surgery. Results Three of 42 patients with normal preoperative serum HbA 1c levels (≦5.8%), and five of 10 patients with elevated preoperative serum HbA 1c levels (>5.8%) showed deterioration of glucose tolerance. Five of these eight patients developed a pancreatic fistula postoperatively. However, the average serum HbA 1c levels of patients with normal preoperative serum HbA 1c levels have remained within the normal range for 3–10 years after surgery. Conclusions Pancreatic endocrine function was maintained for a long‐term period after pancreatoduodenectomy with pancreaticogastrostomy. Impaired glucose tolerance appeared to be associated with postoperative pancreatic fistula formation. J. Surg. Oncol. 2008;97:519–522. © 2008 Wiley‐Liss, Inc.