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Intraductal papillary neoplasm of the bile ducts: The clinical features and surgical outcome of 25 cases
Author(s) -
Paik Kwang Yeol,
Heo Jin Seok,
Choi Seong Ho,
Choi Dong Wook
Publication year - 2008
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20994
Subject(s) - medicine , bile duct , pathological , radiological weapon , surgery , retrospective cohort study , common bile duct , survival rate , neoplasm , radiology , pathology
Background and Objectives Intraductal papillary neoplasm of the bile ducts (IPN‐B) is considered an uncommon tumor. The purpose of this study was to evaluate the clinical, radiological, and histopathological characteristics of IPN‐B, and its prognosis. Methods From October 1995 to August 2006, a retrospective analysis was made of 25 patients that underwent surgery for IPN‐B. Clinical features and radiological, pathological, and operative findings were reviewed, and survival rates were determined. Results In five patients (20.0%), lesions were incidentally found. Radiologically, 23 of the 25 (92.0%) showed bile duct dilatation, bile duct dilatation with or without an intraductal mass, and cystic changes of bile ducts. Twenty three of the 25 patients underwent hepatic resection with or without extrahepatic bile duct resection. No in hospital mortality occurred. Median survival time of resected patients was 59.8 months and 1‐, 2‐, and 4‐year survival rates were 90.5%, 84.0%, and 84.0%, respectively. All six patients with benign IPN‐B remained alive at a mean of 26.2 postoperative months without recurrence. Conclusions A diagnosis of IPN‐B is usually made in patients with biliary dilatation by radiologic study. The prognosis of IPN‐B, especially of the benign category, is excellent. Aggressive surgical resection is the treatment of choice for IPN‐B. J. Surg. Oncol. 2008;97:508–512. © 2007 Wiley‐Liss, Inc.