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Mixed ductal‐endocrine carcinoma derived from intraductal papillary mucinous neoplasm (IPMN) of the pancreas identified by human telomerase reverse transcriptase (hTERT) expression
Author(s) -
Hashimoto Yasushi,
Murakami Yoshiaki,
Uemura Kenichiro,
Hayashidani Yasuo,
Sudo Takeshi,
Ohge Hiroki,
Sueda Taijiro,
Shimamoto Fumio,
Hiyama Eiso
Publication year - 2007
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20959
Subject(s) - pancreas , medicine , endocrine system , telomerase reverse transcriptase , telomerase , intraductal papillary mucinous neoplasm , ductal carcinoma , pathology , carcinoma , cancer research , cancer , biology , breast cancer , hormone , biochemistry , gene
Abstract We report a case of mixed ductal‐endocrine carcinoma derived from intraductal papillary mucinous neoplasm (IPMN) of the pancreas. The tumor presented intermingled exocrine and endocrine carcinomatous components and expressed intense human telomerase reverse transcriptase (hTERT), further confirming the malignant features. This pathologically unique tumor is the first case of mixed ductal‐endocrine carcinoma derived from pancreatic IPMN and telomerase activation could play a potential role in the neoplastic progression of mixed ductal‐endocrine carcinomas of the pancreas. J. Surg. Oncol. 2008;97:469–475. © 2007 Wiley‐Liss, Inc.