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The significances of lymph node micrometastasis and its correlation with E‐cadherin expression in pT1‐T3N0 gastric adenocarcinoma
Author(s) -
Kim JongHan,
Park JoongMin,
Jung CheolWoong,
Park SungSoo,
Kim SeungJoo,
Mok YoungJae,
Kim ChongSuk,
Chae YangSuk,
Bae JeoungWon
Publication year - 2007
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20937
Subject(s) - micrometastasis , medicine , lymph node , lymphovascular invasion , cytokeratin , lymph , cancer , adenocarcinoma , pathology , primary tumor , immunostaining , oncology , immunohistochemistry , metastasis
Abstract Background Recently, micrometastasis (MM) in the lymph node in gastric cancer has been detected by cytokeratin immunostaining. However, clinical significance of MM and its relationship with reduced expression of E‐cadherin in primary lesion have not been well studied. Methods The 4,990 lymph nodes from 184 pT1∼T3N0 patients from 1995 to 2000 at Korea University Hospital were immunostained with the anticytokeratin AE1/3 antibody for detection of micometastasis. The primary lesions were also immunostained for E‐cadherin expression. Results MM in the lymph node of gastric cancer was found in 131 (2.6%) of total dissected nodes, and 31 of 184 patients (16.8%) were shown to have MM. The MM was significantly correlated with the depth of invasion, tumor size, operation method, Lauren classification, lymphovascular invasion and loss of E‐cadherin expression in primary tumor. On multivariate analysis, the independent risk factors for MM were the depth of invasion and loss of E‐cadherin expression. The patients with MM had significantly lower 5‐year overall and disease free survival rate than those without MM. Conclusion Lymph node MM in histologically node‐negative gastric cancer was significantly correlated with poor 5‐year survival rate. The determination of E‐cadherin expression in primary gastric tumor may be useful in prediction of the MM. J. Surg. Oncol. 2008;97:125–130. © 2007 Wiley‐Liss, Inc.