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Curing hepatocellular carcinomatosis with biologic therapy and surgery: Achieving the impossible?
Author(s) -
Thomas Melanie B.,
Tetzlaff Eric,
Lozano Richard,
Samp Leigh,
Butler Charles E.,
Gan Christopher,
Hamilton Stanley,
Vauthey Jean Nicholas,
Abdalla Eddie
Publication year - 2007
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20898
Subject(s) - medicine , hepatocellular carcinoma , peritoneal carcinomatosis , systemic therapy , surgery , adjuvant therapy , adjuvant , radiology , oncology , cancer , chemotherapy , colorectal cancer , breast cancer
Hepatocellular carcinoma (HCC) that present as hemoperitoneum are uncommon, often recur as peritoneal carcinomatosis, and have poor prognosis. Systemic chemotherapies are minimally effective in advanced HCC and less so as neo‐adjuvant therapy. This report describes a 47‐year woman with ruptured HCC who developed recurrent carcinomatosis. She received biologically targeted systemic therapy which resulted in significant radiographic tumor response. Salvage surgery revealed complete pathologic response in all tumor nodules, thus the patient was rendered cancer‐free. J. Surg. Oncol. 2008;97:82–84. © 2007 Wiley‐Liss, Inc.