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Sentinel node biopsy in oral squamous cell carcinoma
Author(s) -
Civantos Francisco,
Zitsch Robert,
Bared Anthony
Publication year - 2007
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20865
Subject(s) - medicine , basal cell , biopsy , sentinel node , carcinoma , oncology , dermatology , pathology , cancer , breast cancer
Abstract The clinical utility of sentinel node biopsy techniques for cutaneous melanoma has led multiple investigators to study the applicability of this approach to other solid tumors, including cancers of the upper aerodigestive tract, and especially the oral cavity. Preliminary data indicate that it may be useful for early oral cancers, with the exception of floor of mouth tumors, where technical challenges related to the proximity of the lymphatic basin remain a problem. A multi‐institutional pathologic validation trial, involving sentinel node biopsy followed by completion selective neck dissection, has completed accrual. While central step sectioning and immunohistochemistry remain to be completed and analyzed, routine pathologic techniques provided negative predictive values of 96% for oral cancer excluding floor of mouth lesions. Subsequent trials need to involve clinical follow‐up and evaluation for recurrence in the neck. We believe this technique may ultimately play a role in the management of early oral cancer. J. Surg. Oncol. 2007;96:330–336. © 2007 Wiley‐Liss, Inc.