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The sentinel concept in patients with cervical cancer
Author(s) -
Schneider Achim
Publication year - 2007
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20864
Subject(s) - medicine , sentinel node , cervical cancer , predictive value , oncology , cancer , radiology , breast cancer
The sentinel concept for patients with early cervical cancer has a high potential for decreasing morbidity and for increasing oncologic safety. The detection rate with technetium‐labeling or a combination with blue dye varies between 84% and 92%. Sensitivity and negative predictive value depend on tumor size: the smaller the tumor, the higher the validity of the technique. Detection of circulating tumor cells in the sentinel node using HPVmRNA as marker may have a good prognostic value. Currently the sentinel concept should only be used in clinical studies before its validity has been proved. J. Surg. Oncol. 2007;96:337–341. © 2007 Wiley‐Liss, Inc.