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Clinicopathological characteristics of patients with hepatocellular carcinoma after hepatectomy: Relationship with status of viral hepatitis
Author(s) -
Nanashima Atsushi,
Abo Takafumi,
Sumida Yorihisa,
Takeshita Hiroaki,
Hidaka Shigekazu,
Furukawa Katsurou,
Sawai Terumitsu,
Yasutake Toru,
Masuda Junichi,
Morisaki Tomohito,
Nagayasu Takeshi
Publication year - 2007
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20855
Subject(s) - medicine , hepatocellular carcinoma , ascites , gastroenterology , liver function , cirrhosis , hepatitis b , viral hepatitis , hepatectomy , hepatitis b virus , hepatitis , group b , group a , carcinoma , immunology , surgery , resection , virus
Abstract Background and Objectives Viral hepatitis may modulate the status of liver dysfunction, tumor biology, and postoperative course in patients with hepatocellular carcinoma (HCC). Methods To determine the characteristics of HCC in different types of viral hepatitis, we conducted a comparative analysis of clinicopathological features and outcomes in 243 Japanese HCC patients following hepatic resection. Patients were divided into four groups; non‐B‐non‐C group, hepatitis B (HBV) group, hepatitis C (HCV) group, and co‐infection with HB, and HC (HBCV) group. Results Liver function was worst and prevalence of cirrhosis was highest in HBCV group than in compare to HBV and non‐B‐non‐C group. The prevalence rates of intrahepatic metastasis, tumor vascular involvement, and low curability in HBCV group were higher than in the other groups. Uncontrolled ascites and hepatic failure were significantly more common in HBCV group than other groups. The disease‐free and overall survival rates of non‐B‐non‐C group were better than those of the other groups; both survival rates were the worst in HBCV group than the other groups. Conclusions HCC patients with co‐infection of HBV and HCV had poorer liver function and more advanced tumors compared with the other groups. This might explain the poor prognosis of such patients. J. Surg. Oncol. 2007;96:487–492. © 2007 Wiley‐Liss, Inc.