Premium
The role of pelvic exenteration and reconstruction for treatment of advanced or recurrent gynecologic malignancies: Analysis of risk factors predicting recurrence and survival
Author(s) -
Park JeongYeol,
Choi Hyuck Jae,
Jeong SeungYong,
Chung Jinsoo,
Park Jung Kun,
Park SangYoon
Publication year - 2007
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20847
Subject(s) - medicine , pelvic exenteration , surgery , multivariate analysis , malignancy , lymph node , metastasis , survival analysis , oncology , cancer
Background and Objectives Pelvic exenteration offers the last chance of cure for some advanced or recurrent gynecologic malignancy patients. The aim of this prospective study was to analyze factors associated with recurrence and survival after pelvic exenteration. Methods Forty‐six women with advanced or recurrent gynecologic malignancies were enrolled between July 2001 and February 2006. All pelvic exenteration surgery was performed by the same gynecological oncologist. Results Two patients were excluded due to the discovery of peritoneal disease during surgery. Multivariate analysis showed that a tumor size >4 cm was the only factor associated with risk of recurrence after surgery ( P = 0.014), that margin status was the only factor associated with disease‐free survival ( P = 0.0.047), and that margin status and lymph node metastasis were associated with overall survival ( P = 0.017 and 0.012, respectively). Conclusions Pelvic exenteration and reconstruction was found to have a potential to provide long‐term survival without postoperative mortality although the morbidity rate is somewhat high. Multivariate analysis showed that tumor size >4 cm was a predictive factor for recurrence, and that margin status and lymph node metastasis were predictive factors for survival. J. Surg. Oncol. 2007;96:560–568. © 2007 Wiley‐Liss, Inc.