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Alleviation of oxidative and nitrosative stress following curative resection in patient with oral cavity cancer
Author(s) -
Rasheed Muzib Hassanal,
Beevi Syed Sultan,
Rajaraman R.,
Bose S.J.C.
Publication year - 2007
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20818
Subject(s) - oxidative stress , lipid peroxidation , medicine , reactive nitrogen species , reactive oxygen species , cancer , oxidative phosphorylation , nitric oxide , gastroenterology , carcinogenesis , surgery , biochemistry , chemistry
Background Oxidative stress by reactive oxygen species (ROS) and nitrosative stress by reactive nitrogen species (RNS) are proven initiators and promoters in carcinogenesis. Elevated ROS/RNS with lowered antioxidants occur in patients with squamous cell carcinoma of oral cavity. Ours is the first study to evaluate the effect of curative resection on both oxidative and nitrosative stress in such patients. Methods This study was conducted on 24 cancer patients and with age‐ and sex‐matched healthy controls. Lipid peroxidation products, nitric oxide (NO) products and ceruloplasmin (CPL) in plasma were measured before and after surgery. Similarly enzymatic antioxidants in erythrocytes and non‐enzymatic antioxidants in plasma were measured. Results Statistically significant elevation of lipid peroxidation, NO products and CPL and depletion of antioxidants were found in cancer patients compared with controls. After curative surgical resection there was a statistically significant fall in oxidants and CPL coupled with a rise in antioxidants. Conclusions Our results suggest that oxidative/nitrosative stress could play a significant role in oral cavity cancer (OCC) and that curative resection is effective in alleviating this oxidative/nitrosative burden. Significant mitigation of oxidative/nitrosative stress could indicate the completeness of resection since tumor forms the major source of oxidants. J. Surg. Oncol. 2007;96: 194–199. © 2007 Wiley‐Liss, Inc.