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The prophylaxis of venous thrombosis in patients with cancer undergoing major abdominal surgery: emerging options
Author(s) -
Agnelli Giancarlo,
Caprini Joseph A.
Publication year - 2007
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20808
Subject(s) - medicine , venous thromboembolism , heparin , surgery , chemotherapy , cancer , thrombosis , low molecular weight heparin , risk factor , abdominal surgery , venous thrombosis
Cancer is a risk factor for venous thromboembolism (VTE). This risk is amplified by treatment with chemotherapy, radiation, or surgery. Thus, patients with cancer undergoing major surgery should receive appropriate prophylaxis. Available agents include low‐dose unfractionated heparin (LDUH), low‐molecular‐weight heparin (LMWH), and Factor Xa inhibitors. Recent data suggest that Factor Xa inhibitors are safe and effective for VTE prevention in patients with cancer undergoing abdominal surgery. Further study in this patient population is warranted. J. Surg. Oncol. 2007;96: 265–272. © 2007 Wiley‐Liss, Inc.